WHICH of the 22,000 genes in a human genome are linked to cancer risk, who has these genetic changes and what should you do if you have them?
The University of Cambridge just released the world's largest study on genes that cause an increased risk of breast cancer, with a significant part of the Asian research led by researchers at Cancer Research Malaysia, University Malaya, Subang Jaya Medical Centre and 7 hospitals in Singapore.
It is a huge milestone for cancer research worldwide and in Asia says Professor Datin Paduka Dr Teo Soo Hwang, chief scientific officer at Cancer Research Malaysia, who co-led the study.
There were over 113,000 participants from different countries, including a substantial number of Asian women.
The huge sample size of the study provides more accurate estimates for patients to understand their breast cancer risk, as well as suitable prevention options for them and their family.
Dr Teo explains that previously, genetic tests for cancers and other diseases were offered to patients sometimes without any genetic counselling or without a complete understanding of what recommendations to take forward in terms of prevention and screening.
"Our study is highly important as it analysed the 34 genes commonly found in gene panel tests, narrowing it down to just 12 genes associated with breast cancer risk. We also discovered that Asians are just as likely as Caucasians to have these faulty genes, but we have a significantly lower lifetime risk of developing breast cancer, compared to Caucasians."
This means screening and prevention recommendations may need to be tailored differently for Asian women.
The study, called BRIDGES, which stands for Breast Cancer Risk after Diagnostic Gene Sequencing was published in the prestigious New England Journal of Medicine.
Its findings will inform doctors, clinicians and even companies that offer genetic tests, on the right set of genes associated with breast cancer risk, to better serve patients and their families.
For Asian women who have a family history of breast or ovarian cancer, knowing their lifetime risk is lower could mean making different decisions about prevention, in consultation with a specialist. Previously, most research focused on European populations.